产品货号：
Q10201
中文名称：
重组SARS-CoV S-RBD(His标签)
英文名称：
SARS-CoV S-RBD Protein(His Tag)
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
纯度：> 95% as determined by SDS-PAGE
内毒素：<1.0 EU per μg of the protein as determined by the LAL method
GenBank No.：AAX16192.1
表达宿主：Baculovirus-Insect Cells
种属：SARS
预测N端：Arg306
蛋白构建：
A DNA sequence encoding the receptor binding domain (RBD) of SARS-CoV (isolate:WH20) spike (AAX16192.1) (Arg306-Phe527) was expressed with a C-terminal polyhistidine tag.
分子量：
The recombinant receptor binding domain (RBD) of SARS-CoV (isolate:WH20) spike comprises 233 amino acids and has a predicted molecular mass of 26.5kDa.The apparent molecular mass of the protein is approximately 35.1kDa in SDS-PAGE under reducing conditions.
制剂：
Lyophilized from sterile 20mM PBS，300mM NaCl，10% glycerol，pH7.0
复溶：
A hardcopy of COA with reconstitution instruction is sent along with the products.Please refer to it for detailed information.
稳定性&储存条件：
Samples are stable for up to 12 months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃.It is recommended that the protein be aliquoted for optimal storage.Avoid repeated freeze-thaw cycles.
背景资料：
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2;DPP4,dipeptidyl peptidase-4;APN,aminopeptidase N;CEACAM,carcinoembryonic antigen-related cell adhesion molecule 1;Sia,sialic acid;O-ac Sia,O-acetylated sialic acid.The spike is essential for both host specificity and viral infectivity.The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together.The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.It's been reported that SARS-CoV-2 (COVID-19 coronavirus,2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.The main functions for the Spike protein are summarized as:Mediate receptor binding and membrane fusion;Defines the range of the hosts and specificity of the virus;Main component to bind with the neutralizing antibody;Key target for vaccine design;Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD),leading to a higher mortality rate.
相关搜索：重组SARS-CoV S-RBD(His标签)，重组SARS病毒受体结合域，SARS Spike RBD Protein，重组SARS-CoV S1-RBD，SARS-CoV S-RBD Protein(His Tag)
内毒素：<1.0 EU per μg of the protein as determined by the LAL method
GenBank No.：AAX16192.1
表达宿主：Baculovirus-Insect Cells
种属：SARS
预测N端：Arg306
蛋白构建：
A DNA sequence encoding the receptor binding domain (RBD) of SARS-CoV (isolate:WH20) spike (AAX16192.1) (Arg306-Phe527) was expressed with a C-terminal polyhistidine tag.
分子量：
The recombinant receptor binding domain (RBD) of SARS-CoV (isolate:WH20) spike comprises 233 amino acids and has a predicted molecular mass of 26.5kDa.The apparent molecular mass of the protein is approximately 35.1kDa in SDS-PAGE under reducing conditions.
制剂：
Lyophilized from sterile 20mM PBS，300mM NaCl，10% glycerol，pH7.0
复溶：
A hardcopy of COA with reconstitution instruction is sent along with the products.Please refer to it for detailed information.
稳定性&储存条件：
Samples are stable for up to 12 months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃.It is recommended that the protein be aliquoted for optimal storage.Avoid repeated freeze-thaw cycles.
背景资料：
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2;DPP4,dipeptidyl peptidase-4;APN,aminopeptidase N;CEACAM,carcinoembryonic antigen-related cell adhesion molecule 1;Sia,sialic acid;O-ac Sia,O-acetylated sialic acid.The spike is essential for both host specificity and viral infectivity.The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together.The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.It's been reported that SARS-CoV-2 (COVID-19 coronavirus,2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.The main functions for the Spike protein are summarized as:Mediate receptor binding and membrane fusion;Defines the range of the hosts and specificity of the virus;Main component to bind with the neutralizing antibody;Key target for vaccine design;Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD),leading to a higher mortality rate.
相关搜索：重组SARS-CoV S-RBD(His标签)，重组SARS病毒受体结合域，SARS Spike RBD Protein，重组SARS-CoV S1-RBD，SARS-CoV S-RBD Protein(His Tag)